IRIDOID GLYCOSIDES FROM THE ROOT OF ACANTHUS SENNII

Iridoid glycosides from the root of Acanthus sennii

Context: Acanthus sennii is a plant traditionally used for the treatment of antifungal, cytotoxic, anti-inflammatory, antipyretic, antioxidant, insecticidal, hepatoprotective, immunomodulatory, anti-platelet aggregation and Hawk Pen Tatto Machines anti-viral potential.Aims: To investigate the phytochemical constituents of roots of Acanthus sennii.M

read more

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Abstract Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops).Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.Using unbiased interactomics, biochemical screening, molecular biology, and Pancake / Crepe Rakes super-

read more

Cytochrome P450 genes expression in human prostate cancer

CYP-dependent metabolites play a critical role in regulating the cell cycle, as well as the proliferative, invasive, and migratory activity of cancer cells.We conducted a study to analyze the relative gene expression of various CYPs (CYP7B1, CYP27A1, CYP39A1, CYP51, CYP1B1, CYP3A5, CYP4F8, CYP5A1, CYP4F2, CYP2J2, CYP2E1, CYP2R1, CYP27B1, CYP24A1) i

read more